Dementia, lewy body

Preferred Label : Dementia, lewy body;

Symbol : DLB;

CISMeF acronym : DLB;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Lewy body dementia; Diffuse lewy body disease;

Included titles and symbols : Diffuse lewy body disease with gaze palsy; Lewy body variant of alzheimer disease;

Description : Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Pathologically, Lewy bodies are present in a pattern more widespread than usually observed in Parkinson disease (see PD; 168600). Alzheimer disease (AD; 104300)-associated pathology and spongiform changes may also be seen (McKeith et al., 1996; Mizutani, 2000; McKeith et al., 2005).;

Inheritance : Autosomal dominant;

Molecular basis : Caused by mutation in the alpha-synuclein gene (SNCA, 163890.0004); Caused by mutation in the beta-synuclein gene (SNCB, 602569.0001);

Prefixed ID : #127750;

Details

Origin ID

127750;

UMLS CUI

C0752347;

Automatic exact mappings (from CISMeF team)
- diffuse lewy body disease with gaze palsy [MeSH concept]
- diffuse lewy body disease with gaze palsy [MeSH Supplementary Concept]
- lewy body variant of alzheimer disease [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Dementia due to Lewy body disease [ICD-11 Category]
- Dementia with Lewy bodies [MedDRA Preferred Term]
- Dementia with Lewy body [ORDO Disease]
- Dementia with lewy bodies [ICD-9 code]
- Diffuse Lewy body disease [MedDRA LLT]
- Diffuse Lewy body disease (disorder) [SNOMED CT concept]
- Lewy Body Dementia [NCIt concept]
- Lewy body dementia [PASCAL descriptor]
- Lewy body dementia [DO Concept]
- Lewy body dementia [TUV Concept]
- Lewy body dementia [TUV Term]
- Lewy body disease [Disease (Nov.)]
- Senile dementia of the Lewy body type (disorder) [SNOMED CT concept]
- dementia with Lewy bodies [Radlex concept]
- diffuse lewy body disease [SNOMED Notion]
- lewy body dementia [MedlinePlus Topic]
- lewy body disease [MeSH Descriptor]
- lewy body disease [MeSH concept]
- lewy body variant of alzheimer disease [MeSH concept]
DO Cross reference
- Lewy body dementia [DO Concept]
Genes related to phenotype
- Glucosidase, beta, acid [OMIM gene]
- Synuclein, alpha [OMIM gene]
- Synuclein, beta [OMIM gene]
HPO term(s)
- Autosomal dominant inheritance [HPO term]
- Delusions [HPO term]
- Dementia [HPO term]
- Dementia, progressive [HPO term]
- Fluctuations in consciousness [HPO term]
- Lewy bodies [HPO term]
- Parkinsonism [HPO term]
- Visual hallucinations [HPO term]
ORDO concept(s)
- Dementia with Lewy body [ORDO Disease]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Dementia with Lewy bodies [MedDRA Preferred Term]
- Dementia with Lewy body [ORDO Disease]
- Dementia with lewy bodies [ICD-9 code]
- Diffuse Lewy body disease [MedDRA LLT]
- Diffuse Lewy body disease (disorder) [SNOMED CT concept]
- Lewy Body Dementia [NCIt concept]
- Lewy body dementia [TUV Concept]
- Lewy body dementia [TUV Term]
- Lewy body dementia [DO Concept]
- Lewy body dementia [PASCAL descriptor]
- Lewy body disease [Disease (Nov.)]
- Senile dementia of the Lewy body type (disorder) [SNOMED CT concept]
- dementia with Lewy bodies [Radlex concept]
- diffuse lewy body disease [SNOMED Notion]
- lewy body dementia [MedlinePlus Topic]
- lewy body disease [MeSH Descriptor]
- lewy body disease [MeSH concept]

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