Preferred Label : Phospholipase a2, group iva;
Symbol : PLA2G4A;
CISMeF acronym : PLA2G4A;
Type : Gene;
Alternative titles and symbols : Phospholipase a2, cytosolic, calcium-dependent, alpha; CPLA2-ALPHA;
Description : Cytosolic phospholipase A2 (PLA2; EC 3.1.1.4) catalyzes the release of arachidonic
acid from membrane phospholipids. Arachidonic acid in turn serves as precursor for
a wide spectrum of biologic effectors, collectively known as eicosanoids, that are
involved in hemodynamic regulation, inflammatory responses, and other cellular processes
(summary by Tay et al., 1995). (Eicosanoids are lipid mediators of inflammation; they
include a variety of compounds (prostaglandins, thromboxanes, leukotrienes, hydroxy-
and epoxy-fatty acids, lipoxins, and isoprostanes) that are derived from the ubiquitous
20-carbon atom arachidonate (20 in Greek is 'eicosa') and a few similar polyunsaturated
fatty acids (summary by De Caterina and Zampolli, 2004).) Dennis (1994) reviewed various
types of PLA2. The best characterized is the group II PLA2 originally isolated from
human synovial fluid (i.e., PLA2G2A; 172411). Groups I (human pancreatic, PLA2G1B
(172410); also found in cobras and kraits), II (synovial; also found in rattlesnakes
and vipers), and III (forms of which were described in bee and lizard) are secreted;
group IV is cytosolic.;
Ensembl ID : ENSG00000116711;
Prefixed ID : *600522;
Origin ID : 600522;
UMLS CUI : C1418620;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- HGNC gene
- NCIt concept(s)
- ORDO concept(s)
- Phenotypes related
- Semantic type(s)
- UMLS correspondences (same concept)
