Phosphofructokinase-2

Preferred Label : Phosphofructokinase-2;

MeSH definition : An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.;

MeSH synonym : atp-d-fructose-6-phosphate 2-phosphotransferase; fructose-6-phosphate,2-kinase; fructose-6-p,2-kinase; fru-6-p,2-kinase; 6pf2k; 6-phosphofructo-2-kinase; phosphofructokinase 2;

MeSH Hyperonym : 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase; Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase; 6-PF-2-K-Fru-2,6-P(2)ase; F Kinase-F-bisphosphatase; Fru-kinase-Fru-bisphosphatase;

MeSH hyponym : Fructose-2,6-bisphosphatase; Fructose-2,6-bisphosphate 2-phosphatase; fructose-2,6-diphosphatase; Fructose 2,6-bisphosphatase;

CISMeF hyponym : EC 3.1.3.46;

MeSH Related Number : Fructose-2,6-bisphosphatase; EC 3.1.3.46;

Registry Number MeSH : EC 2.7.1.105;

Related CAS MeSH : EC 3.1.3.46 (Fructose-2,6-bisphosphatase);

Wikipedia link : https://en.wikipedia.org/wiki/Phosphofructokinase 2;

Is substance : O;

UNII : EC 2.7.1.105;

Details

Origin ID

D025481;

UMLS CUI

C0049700;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase [MeSH concept]
- Fructose-2,6-bisphosphatase [MeSH concept]
- Phosphofructokinase-2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PFKFB2 protein, human [MeSH Supplementary Concept]
- PFKFB3 protein, human [MeSH Supplementary Concept]
- PFKFB3 protein, mouse [MeSH Supplementary Concept]
- PFKFB4 protein, Xenopus [MeSH Supplementary Concept]
- PFKFB4 protein, human [MeSH Supplementary Concept]
- Pfkfb2 protein, mouse [MeSH Supplementary Concept]
- Pfkfb3 protein, rat [MeSH Supplementary Concept]
- Pfkfb4 protein, mouse [MeSH Supplementary Concept]
- Pfkfb4 protein, rat [MeSH Supplementary Concept]
See also
- Phosphofructokinase-1 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 6-phosphofructo-2-kinase [SNOMED Notion]
- 6-phosphofructo-2-kinase (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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