Preferred Label : dna, circular;
MeSH definition : Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria,
plastids, and plasmids. Small, polydisperse circular DNA's have also been observed
in a number of eukaryotic organisms and are suggested to have homology with chromosomal
DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is
a fragment of DNA formed by a process of looping out and deletion, containing a constant
region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA
is a normal product of rearrangement among gene segments encoding the variable regions
of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et
al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992);
MeSH synonym : circular dna; circular DNAs; DNAs, circular;
MeSH annotation : IM; /drug eff /ultrastruct permitted;
Is substance : O;
Origin ID : D004270;
UMLS CUI : C0012925;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria,
plastids, and plasmids. Small, polydisperse circular DNA's have also been observed
in a number of eukaryotic organisms and are suggested to have homology with chromosomal
DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is
a fragment of DNA formed by a process of looping out and deletion, containing a constant
region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA
is a normal product of rearrangement among gene segments encoding the variable regions
of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et
al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
