Preferred Label : Neurexins;
MeSH definition : Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent
trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their
PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE
SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases
such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.;
Origin ID : D000096784;
UMLS CUI : C5828374;
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Semantic type(s)
Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent
trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their
PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE
SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases
such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.