Preferred Label : Amifampridine;

MeSH definition : 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.;

MeSH synonym : 3,4-Diaminopyridine; 3,4 Diaminopyridine;

MeSH CAS label : 3,4-Pyridinediamine;

MeSH Related Number : 54-96-6 (Amifampridine); 8HF8FIN815;

Wikipedia link : https://en.wikipedia.org/wiki/Amifampridine;

UNII : RU4S6E2G0J;

Details


Main resources

You can consult :

4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.

https://recalls-rappels.canada.ca/fr/avis-rappel/ruzurgi-amifampridine-retrait-du-marche-canadien-options-pour-poursuite-du-traitement
2023
false
false
false
Canada
French
English
Ruzurgi
Amifampridine
canada
drug approval
lambert-eaton myasthenic syndrome
drug information

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https://www.ema.europa.eu/en/medicines/human/EPAR/amifampridine-serb
2022
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
Amifampridine
Amifampridine
amifampridine
drugs, generic

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RUZURGI (amifampridine) - Removal from Canadian Market: Options for Continued Treatment for Lambert-Eaton Myasthenic Syndrome
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2021/75793a-fra.php
2021
false
false
false
Canada
French
English
product recalls and withdrawals
Amifampridine
canada
drug information
lambert-eaton myasthenic syndrome
amifampridine
Product containing only amifampridine in oral dose form (medicinal product form)

---
https://www.inesss.qc.ca/fileadmin/doc/INESSS/Inscription_medicaments/Avis_au_ministre/Mai_2021/Ruzurgi_2021_04.pdf
2021
false
false
false
Canada
French
drug evaluation
Amifampridine

---
http://www.has-sante.fr/portail/jcms/c_2757143/fr/firdapse
2017
false
false
France
French
administration, oral
potassium channel blockers
treatment outcome
4-Aminopyridine
insurance, health, reimbursement
amifampridine
adult
lambert-eaton myasthenic syndrome
evaluation of the transparency committee
Amifampridine
Amifampridine

---
https://www.ema.europa.eu/medicines/human/EPAR/firdapse-previously-zenas
2012
false
United Kingdom
French
English
syndication feed
lambert-eaton myasthenic syndrome
potassium channel blockers
orphan drug production
potassium channel blockers
amifampridine
drug approval
drug labeling
treatment outcome
adult
administration, oral
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
4-Aminopyridine
summary of product characteristics
package leaflet
drug evaluation
Amifampridine
Amifampridine

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69935992
2012
France
summary of product characteristics
package leaflet
tablets
Amifampridine

---
http://www.has-sante.fr/portail/jcms/c_991360/firdapse-amifampridine-bloqueur-des-canaux-k-voltage-dependants
http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-06/firdapse_-_ct-8001.pdf
2010
false
France
French
potassium channel blockers
lambert-eaton myasthenic syndrome
adult
insurance, health, reimbursement
4-Aminopyridine
administration, oral
amifampridine
treatment outcome
guidelines for drug use
evaluation of the transparency committee
Amifampridine

---
http://www.has-sante.fr/portail/jcms/c_962465/firdapse
2010
false
France
French
guidelines for drug use
administration, oral
potassium channel blockers
treatment outcome
4-Aminopyridine
insurance, health, reimbursement
amifampridine
adult
lambert-eaton myasthenic syndrome
evaluation of the transparency committee
Amifampridine
Amifampridine

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/34-Diaminopyridine-34-DAP.aspx
2010
false
Canada
French
English
child
4-Aminopyridine
amifampridine
patient education handout
drug information
Amifampridine
Amifampridine

---
https://www.ema.europa.eu/medicines/human/EPAR/firdapse-previously-zenas
2010
false
false
false
United Kingdom
drug approval
europe
Amifampridine
Amifampridine
orphan drug production
adult
lambert-eaton myasthenic syndrome
neuromuscular agents
neuromuscular agents
administration, oral
potassium channel blockers
potassium channel blockers
product surveillance, postmarketing
drug interactions
pregnancy
breast feeding
amifampridine
drug evaluation, preclinical
syndication feed

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07/06/2025


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