Preferred Label : Perilipins;
MeSH definition : A family of vertebrate and insect lipid droplet associated proteins. They consist
of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids),
an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles
near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS
in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE
and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis
as well as the regulation of lipid metabolism. Genetic variations in perilipins are
associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.;
MeSH synonym : Perilipin-Adipophilin-TIP47 Proteins; Perilipin Adipophilin TIP47 Proteins; Proteins, Perilipin-Adipophilin-TIP47; PLIN Proteins; Proteins, PLIN; PAT Proteins; Proteins, PAT; Perilipin Proteins; Proteins, Perilipin;
Origin ID : D000070137;
UMLS CUI : C4277675;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
A family of vertebrate and insect lipid droplet associated proteins. They consist
of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids),
an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles
near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS
in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE
and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis
as well as the regulation of lipid metabolism. Genetic variations in perilipins are
associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
