" /> apical ectodermal ridge - CISMeF





Preferred Label : apical ectodermal ridge;

Uberon definition : multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].;

Uberon synonym : apical epidermal ridge;

Uberon related term : AER;

Uberon Function note : maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop;

Uberon Taxon note : The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold;

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multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].

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04/05/2025


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