Preferred Label : epiblast (generic);
Uberon definition : In amniote animal embryology, the epiblast is a tissue type derived either from the
inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above
the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are
adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer
to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates
to form all three layers of the trilaminar germ disc in a process called gastrulation[WP].
The outer of the two layers of the blastoderm that form during gastrulation, corresponding
to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA];
Uberon synonym : epiblast;
Uberon related term : blastocyst; ectoblast; primitive ectoderm;
Uberon Homology note : In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits
on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation
initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo
an epithelial to mesenchymal transition (EMT), migrate through the primitive streak
(PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive
definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic
tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which
form supporting structures such as the yolk sac.[uncertain][VHOG];
Origin ID : 0002532;
Automatic exact mappings (from CISMeF team)
- Uberon cross reference
- adjacent to
- develops into
- has part
- part of
- surrounded by
- surrounds
In amniote animal embryology, the epiblast is a tissue type derived either from the
inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above
the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are
adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer
to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates
to form all three layers of the trilaminar germ disc in a process called gastrulation[WP].
The outer of the two layers of the blastoderm that form during gastrulation, corresponding
to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]
