Uberon definition : A specialized region of ectoderm found between the neural ectoderm (neural plate)
and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate
in early embryonic development from the dorsal neural tube and give rise to an astounding
variety of differentiated cell types[MP].;
Uberon synonym : NC;
Uberon related term : neural crest material;
Uberon Homology note : A well developed neural crest population is present in lampreys (Horigome et al. 1999
; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian
(Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal
denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial
bars in lamprey ammocoete larvae), suggests that neural crest arose very early in
vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates
apparently lack defini- tive neural crest. One marker of migrating neural crest in
some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos
(Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges
of the neural plate and adjacent nonneural ectoderm share some properties of neural
crest[PMID:11523831];
A specialized region of ectoderm found between the neural ectoderm (neural plate)
and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate
in early embryonic development from the dorsal neural tube and give rise to an astounding
variety of differentiated cell types[MP].