Preferred Label : liver;
Uberon definition : An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate
and fat, synthesizes substances involved in the clotting of the blood, synthesizes
vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out
erythrocytes[GO].;
Uberon Function note : secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes
substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies
poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].;
Uberon Homology note : All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior
gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...)
A liver evolved that, among its many functions, stores considerable energy as glycogen
or lipid (reference 2).[well established][VHOG];
Uberon Taxon note : An organ sometimes referred to as a liver is found associated with the digestive tract
of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not
a metabolic organ, and it is unclear how truly homologous it is to the vertebrate
liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes
are not clearly organized in cords or lobules and the typical portal triads are not
apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore,
a clear distinction can be made between the male and female liver in the adult zebrafish.
The female hepatocytes are very basophilic (Figure 15c) as a result of the production
of vitellogenin (Van der Ven et al. 2003).;
Origin ID : 0002107;
UMLS CUI : C0023884;
Automatic exact mappings (from CISMeF team)
- Liver [ICHI extension code]
- Liver [ICHI extension code]
- Currated CISMeF NLP mapping
- Liver [ICD-11 Extension code]
- liver [Blood Transfusion thesaurus concept]
- liver [Artificial nutrition thesaurus concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- Uberon cross reference
- contributes to morphology of
- develops from
- has part
- location of
- part of
- produces
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate
and fat, synthesizes substances involved in the clotting of the blood, synthesizes
vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out
erythrocytes[GO].
