Preferred Label : endocrine system;
Uberon definition : Anatomical system that consists of the glands and parts of glands that produce endocrine
secretions and help to integrate and control bodily metabolic activity.;
Uberon synonym : systema endocrinum; endocrine glandular system;
Uberon Homology note : Multicellular organisms have complex endocrine systems, allowing responses to environmental
stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors
(NRs), a metazoan-specific family of ligand-activated transcription factors, play
central roles in endocrine responses, as intermediates between signaling molecules
and target genes. The NR family includes ligand-bound and orphan receptors, that is,
receptors with no known ligand or for which there is no ligand Pocket. Understanding
NR evolution has been further improved by comparison of several completed genomes,
particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR
ligands is still much debated. One hypothesis proposes that several independent gains
and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes.
A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors
and estrogen related receptor), proposes that before the divergence of protostomes
and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated
and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our
analysis reveals that steroidogenesis has been independently elaborated in the 3 main
bilaterian lineages (...).[well established][VHOG];
Origin ID : 0000949;
UMLS CUI : C0014136;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Uberon cross reference
- composed primarily of
- existence ends during
- has part
Anatomical system that consists of the glands and parts of glands that produce endocrine
secretions and help to integrate and control bodily metabolic activity.
