" /> hypoblast (generic) - CISMeF





Preferred Label : hypoblast (generic);

Uberon synonym : hypoblast;

Uberon related term : endomesoderm; future endoderm and mesoderm; mesendoderm;

Uberon Homology note : In mammal and avian, extraembryonic endoderm such as visceral endoderm and hypoblast play essential roles in the embryonic axis formation and germ layer development. These extraembryonic tissues are generally considered to have been created in ancestral amniotes evolved from the Xenopus-type ancestor (reference 1); The endomesoderm secretes as yet unidentified signals that posteriorize the ectoderm, which would otherwise adopt an anterior fate. Our results point to a conserved function at the base of deuterostomes for beta-catenin in germ layer specification and to a causal link in the definition of the posterior part of the embryonic ectoderm by way of activating posteriorizing endomesodermal factors (reference 2).[well established][VHOG];

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25/05/2025


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