Preferred Label : kernicterus;
RADLEX synonyms : bilirubin-induced encephalopathy; bilirubin-induced neurologic dysfunction; BIND Bilirubin encephalopathy; kemicterus;
Definition : A term used pathologically to describe bilirubin staining of the basal ganglia; brain
stem; and cerebellum and clinically to describe a syndrome associated with HYPERbilirubinEMIA.
Clinical features include athetosis, muscle spasticity or hypotonia, impaired vertical
gaze, and deafness. Nonconjugated bilirubin enters the brain and acts as a neurotoxin,
often in association with conditions that impair the blood-brain barrier (e.g., sepsis).
This condition occurs primarily in neonates (infant, newborn), but may rarely occur
in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) [MeSH];
UMLS CUI (RADLEX) : C0022610;
Origin ID : RID5059;
UMLS CUI : C0022610;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
A term used pathologically to describe bilirubin staining of the basal ganglia; brain
stem; and cerebellum and clinically to describe a syndrome associated with HYPERbilirubinEMIA.
Clinical features include athetosis, muscle spasticity or hypotonia, impaired vertical
gaze, and deafness. Nonconjugated bilirubin enters the brain and acts as a neurotoxin,
often in association with conditions that impair the blood-brain barrier (e.g., sepsis).
This condition occurs primarily in neonates (infant, newborn), but may rarely occur
in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) [MeSH]
