Preferred Label : kernicterus;
MeSH definition : A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN
STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA.
Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical
gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin,
often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS).
This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur
in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613);
MeSH synonym : bilirubin encephalopathies; bilirubin encephalopathy; encephalopathy, hyperbilirubinemic; hyperbilirubinemic encephalopathy; encephalopathies, bilirubin; encephalopathy, bilirubin; encephalopathies, hyperbilirubinemic; hyperbilirubinemic encephalopathies;
Wikipedia link : https://en.wikipedia.org/wiki/Kernicterus;
Origin ID : D007647;
UMLS CUI : C0022610;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- HPO term
- MedlinePlus topic(s)
- Metaterm(s)
- Record concept(s)
- See also (suggested by CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN
STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA.
Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical
gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin,
often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS).
This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur
in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
