CARS/ALK Fusion Gene

Preferred Label : CARS/ALK Fusion Gene;

NCIt synonyms : CARS-ALK Fusion Gene; ALK/CARS Fusion Gene; CARS1::ALK Fusion Gene; CARS::ALK Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(2;11)(p23;p15) which fuses most of the CARS gene with the last ten exons of the ALK gene. This fusion is associated with both inflammatory myofibroblastic tumors and anaplastic large cell lymphoma.;

NCIt note : OMIM states that the cause of this gene fusion is a complex translocation t(2;11;2)(p23;p15;q31).;

Details

Origin ID

C99871;

UMLS CUI

C3151473;

Automatic exact mappings (from CISMeF team)
- Anaplastic lymphoma kinase [OMIM gene]
- Cysteinyl-trna synthetase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CARS/ALK Fusion Protein [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- CARS1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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