TPR/MET Fusion Protein

Preferred Label : TPR/MET Fusion Protein;

NCIt synonyms : TPR-MET Oncoprotein; Nucleoprotein TPR/Hepatocyte Growth Factor Receptor Fusion Protein; TPR::MET Fusion Protein;

NCIt definition : A fusion protein (523 aa, 60 kDa) encoded by the TPR/MET fusion gene. This protein is comprised of approximately 140 N-terminal amino acids of the nucleoprotein TPR, including two leucine zipper motifs, fused to the intracellular tyrosine kinase domain of the hepatocyte growth factor receptor protein.;

NCIt note : The TPR/MET fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99863;

UMLS CUI

C0029011;

Automatic exact mappings (from CISMeF team)
- oncogene protein tpr-met [MeSH Descriptor]
- oncogene protein tpr-met [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- oncogene protein tpr-met [MeSH concept]
- oncogene protein tpr-met [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- TPR/MET Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- MET Gene [NCIt concept]
- TPR Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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