NCOA4/RET Fusion Protein

Preferred Label : NCOA4/RET Fusion Protein;

NCIt synonyms : RFG-RET Fusion Protein; RET/NCOA4 Oncoprotein; ELE1-RET Fusion Protein; PTC3 Chimeric Oncoprotein; RFG/RET Fusion Protein; Nuclear Receptor Coactivator 4/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein; NCOA4-RET Fusion Protein; ELE1/RET Fusion Protein; NCOA4::RET Fusion Protein;

NCIt definition : A fusion protein encoded by the NCOA4/RET fusion gene. This protein is comprised of approximately 240 N-terminal amino acids of the nuclear receptor coactivator 4 protein, fused with most of the C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain.;

NCIt note : The NCOA4/RET fusion protein is a constitutively activated tyrosine kinase.;

Details

Origin ID

C99848;

UMLS CUI

C3275000;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- NCOA4/RET Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- NCOA4 Gene [NCIt concept]
- RET Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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