PRKAR1A/RET Fusion Protein

Preferred Label : PRKAR1A/RET Fusion Protein;

NCIt synonyms : R1alpha/ret Fusion Protein; RIA/RET Fusion Protein; PTC2 Chimeric Oncoprotein; ret/PTC2 Oncoprotein; PTC2-RET Fusion Protein; PRKAR1A-RET Fusion Protein; cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein; RIA-RET Fusion Protein; PRKAR1A::RET Fusion Protein;

NCIt definition : A fusion protein encoded by the PRKAR1A/RET fusion gene. This protein is comprised of approximately 240 N-terminal amino acids of the cAMP-dependent protein kinase type I-alpha regulatory subunit protein, including a dimerization domain, fused with most of the C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain.;

NCIt note : The PRKAR1A/RET fusion protein is a constitutively dimerized and activated tyrosine kinase.;

PubMed : 7678053;

Details

Origin ID

C99846;

UMLS CUI

C3274999;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- PRKAR1A/RET Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- PRKAR1A Gene [NCIt concept]
- RET Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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