FGFR1OP2/FGFR1 Fusion Gene

Preferred Label : FGFR1OP2/FGFR1 Fusion Gene;

NCIt synonyms : FGFR1/FGFR1OP2 Fusion Gene; FGFR1OP2-FGFR1 Fusion Gene; FGFR1OP2::FGFR1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal insertion ins(12;8)(p11;p11p22) that fuses exon 4 of the FGFR1OP2 gene with exon 9 of the FGFR1 gene. This translocation is associated with 8p11 myeloproliferative disorder.;

NCIt note : Since the direction of FGFR1OP2 transcription is in the opposite orientation to the direction of FGFR1 transcription, an inversion must have taken place during the formation of the chimeric gene. (OMIM);

Details

Origin ID

C99835;

UMLS CUI

C1851030;

Automatic exact mappings (from CISMeF team)
- Fibroblast growth factor receptor 1 [OMIM gene]
- Fibroblast growth factor receptor 1 oncogene partner 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FGFR1OP2/FGFR1 Fusion Protein [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- FGFR1 Gene [NCIt concept]
- FGFR1OP2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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