MESDC2/SENP1 Fusion Protein

Preferred Label : MESDC2/SENP1 Fusion Protein;

NCIt synonyms : MESDC2-SENP1 Fusion Protein; MESE; LDLR Chaperone MESD/Sentrin-Specific Protease 1 Fusion Protein; MESD::SENP1 Fusion Protein; MESDC2::SENP1 Fusion Protein;

NCIt definition : A fusion protein encoded by the MESDC2/SENP1 fusion gene. This protein is comprised of the signal peptide of the LDLR chaperone MESD protein, fused to all but the first 8 amino acids of the sentrin-specific protease 1 protein, including the nuclear localization and protease domains.;

NCIt note : Sentrin-specific protease 1 cleaves SUMO-1 from target proteins. The MESDC2/SENP1 fusion protein retains this activity. (Hum. Mol. Genet. 2005; 14: 1955-1963.);

PubMed : 15917269;

Details

Origin ID

C99746;

UMLS CUI

C3537413;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- MESDC2/SENP1 Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Proteolysis [NCIt concept]
related_to_genetic_biomarker
- MESD Gene [NCIt concept]
- SENP1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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