CRTC1/MAML2 Fusion Protein

Preferred Label : CRTC1/MAML2 Fusion Protein;

NCIt synonyms : CREB-Regulated Transcription Coactivator 1/Mastermind-Like Protein 2 Fusion Protein; CRTC1-MAML2 Fusion Oncoprotein; MECT1/MAML2 Fusion Protein; TORC1-MAML2 Fusion Protein; WAMTP1-MAML2 Fusion Protein; CRTC1::MAML2 Fusion Protein;

NCIt definition : A fusion protein (1024 aa, 112 kDa) encoded by the CRTC1/MAML2 fusion gene. This protein is comprised of the first 42 N-terminal amino acids of the CREB-regulated transcription coactivator 1 protein fused to most of the mastermind-like protein 2.;

NCIt note : The CRTC1/MAML2 fusion protein activates transcription of the Notch target gene HES1 independently of both Notch ligand and CSL. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

Details

Origin ID

C99742;

UMLS CUI

C3274896;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CRTC1/MAML2 Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_has_abnormality
- CRTC1-MAML2 Fusion Protein Expression [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Activation [NCIt concept]
related_to_genetic_biomarker
- CRTC1 Gene [NCIt concept]
- MAML2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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