EML4/ALK Fusion Protein Variant 3a

Preferred Label : EML4/ALK Fusion Protein Variant 3a;

NCIt synonyms : Fusion Protein EML4-ALK Variant 3 Splicing Isoform a; EML4-ALK Fusion Protein Variant 3a; Echinoderm Microtubule-Associated Protein-Like 4/ALK Tyrosine Kinase Receptor Fusion Protein Variant 3a; EML4::ALK Fusion Protein Variant 3a;

NCIt definition : A fusion protein (785 aa, 86 kDa) that is encoded by the EML4/ALK variant 3a fusion gene. This protein contains the amino acids encoded by exons 1-6a of the echinoderm microtubule-associated protein-like 4 and the entire cytoplasmic region of the ALK tyrosine kinase receptor protein including the tyrosine kinase domain.;

NCIt note : The EML4/ALK fusion protein variant 3a is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99736;

UMLS CUI

C3274891;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EML4/ALK Fusion Gene [NCIt concept]
- EML4/ALK Fusion Gene Variant 3a [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- EML4 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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