Preferred Label : EML4/ALK Fusion Protein Variant 2;
NCIt synonyms : Fusion Protein EML4-ALK Variant 2; EML4-ALK Fusion Protein Variant 2; Echinoderm Microtubule-Associated Protein-Like 4/ALK Tyrosine Kinase Receptor Fusion
Protein Variant 2; EML4::ALK Fusion Protein Variant 2;
NCIt definition : A fusion protein (1310 aa, 146 kDa) that is encoded by the EML4/ALK variant 2 fusion
gene. This protein is comprised of the most of the echinoderm microtubule-associated
protein-like 4 fused to the entire cytoplasmic domain of the ALK tyrosine kinase receptor
protein including the tyrosine kinase domain.;
NCIt note : The EML4/ALK fusion protein variant 2 is a constitutively dimerized and activated
tyrosine kinase.;