Preferred Label : EML4/ALK Fusion Protein Variant 1;
NCIt synonyms : Fusion Protein EML4-ALK Variant 1; Echinoderm Microtubule-Associated Protein-Like 4/ALK Tyrosine Kinase Receptor Fusion
Protein Variant 1; EML4-ALK Fusion Protein Variant 1; EML4::ALK Fusion Protein Variant 1;
NCIt definition : A fusion protein (1059 aa, 117 kDa) that is encoded by the EML4/ALK variant 1 fusion
gene. This protein is comprised of the N-terminal half of the echinoderm microtubule-associated
protein-like 4 fused to the entire cytoplasmic domain of the ALK tyrosine kinase receptor
protein including the tyrosine kinase domain.;
NCIt note : The EML4/ALK fusion protein variant 1 is a constitutively dimerized and activated
tyrosine kinase.;