EML4/ALK Fusion Protein

Preferred Label : EML4/ALK Fusion Protein;

NCIt synonyms : Echinoderm Microtubule-Associated Protein-Like 4/ALK Tyrosine Kinase Receptor Fusion Protein; EML4-ALK Fusion Protein; EML4::ALK Fusion Protein;

NCIt definition : A fusion protein encoded by the EML4/ALK fusion gene. This protein is comprised of the N-terminal portion of the echinoderm microtubule-associated protein-like 4 fused to the C-terminus of the ALK tyrosine kinase receptor protein including the entire cytoplasmic portion with the tyrosine kinase domain.;

NCIt note : The EML4/ALK fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99733;

UMLS CUI

C3274888;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EML4/ALK Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ALK Gene [NCIt concept]
- EML4 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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