ERC1/RET Fusion Protein

Preferred Label : ERC1/RET Fusion Protein;

NCIt synonyms : ELKS/Rab6-Interacting/CAST Family Member 1/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein; ELKS/RET Fusion Protein; ELKS-RET Fusion Protein; ERC1-RET Fusion Protein; ERC1::RET Fusion Protein;

NCIt definition : A fusion protein encoded by the ERC1/RET fusion gene. This protein is comprised of the N-terminal half of the ELKS/Rab6-interacting/CAST family member 1 protein, including the coiled-coil domain, fused with most of the C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain.;

NCIt note : The ERC1/RET fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99722;

UMLS CUI

C3274878;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERC1/RET Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ERC1 Gene [NCIt concept]
- RET Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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