RARA/PML Fusion Gene

Preferred Label : RARA/PML Fusion Gene;

NCIt synonyms : RARA-PML Fusion Gene; RARA::PML Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 2 exons of the RARA gene with the last six exons of the PML gene. A transcript of this gene fusion is associated with acute promyelocytic leukemia.;

NCIt note : The RARA/PML gene may or may not be expressed. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

Details

Origin ID

C99682;

UMLS CUI

C3888082;

Automatic exact mappings (from CISMeF team)
- Acute promyelocytic leukemia, inducer of [OMIM gene]
- Retinoic acid receptor, alpha [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
related_to_genetic_biomarker
- PML Gene [NCIt concept]
- RARA Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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