RABEP1/PDGFRB Fusion Protein

Preferred Label : RABEP1/PDGFRB Fusion Protein;

NCIt synonyms : RABEP1-PDGFRB Fusion Protein; RABPT5-PDGFRB Fusion Protein; Rab GTPase-Binding Effector Protein 1/Beta-Type Platelet-Derived Growth Factor Receptor Fusion Protein; RABPT5/PDGFRB Fusion Protein; RABEP1::PDGFRB Fusion Protein;

NCIt definition : A fusion protein (1318, 150 kDa) encoded by the RABEP1/PDGFRB fusion gene. This protein is comprised of 85% of the Rab GTPase-binding effector protein 1, including 3 and a half of the coiled coil domains, fused to the C-terminal transmembrane and cytoplasmic domains of the beta-type platelet-derived growth factor receptor protein, including the protein kinase domain.;

NCIt note : The RABEP1/PDGFRB fusion protein is a constitutively dimerized and activated tyrosine kinase.;

PubMed : 11588050;

Details

Origin ID

C99592;

UMLS CUI

C3274816;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- RABEP1/PDGFRB Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- PDGFRB Gene [NCIt concept]
- RABEP1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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