" /> Imidapril Hydrochloride - CISMeF





Preferred Label : Imidapril Hydrochloride;

NCIt synonyms : (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic Acid, Hydrochloride;

NCIt definition : The hydrochloride salt of imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 7NSF9GG1NU;

InChIKey : LSLQGMMMRMDXHN-GEUPQXMHSA-N;

CAS number : 89396-94-1;

Chemical formula : C20H27N3O6.ClH;

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07/05/2025


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