Preferred Label : PHGDH wt Allele;

NCIt synonyms : PGD; SERA; PDG; 3PGDH; PGDH3; PGDH; 3-PGDH; Phosphoglycerate Dehydrogenase wt Allele; PGAD;

NCIt definition : Human PHGDH wild-type allele is located in the vicinity of 1p12 and is approximately 84 kb in length. This allele, which encodes D-3-phosphoglycerate dehydrogenase protein, is involved in both amino acid biosynthesis and oxidoreductase activity. Mutation of the gene is associated with phosphoglycerate dehydrogenase deficiency.;

NCIt note : Recent studies have implicated aberrant expression of this gene and its role in serine synthesis in breast cancer tumorigenesis. (Nature. 2011; 476: 346-350.);

GenBank Accession Number : BC011262;

PubMed : 21760589;

Details


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https://www.has-sante.fr/jcms/p_3534500/fr/mentor
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