ETV6/PDGFRB Fusion Protein

Preferred Label : ETV6/PDGFRB Fusion Protein;

NCIt synonyms : ETV6-PDGFRB Fusion Protein; Transcription Factor ETV6/Beta-Type Platelet-Derived Growth Factor Receptor Fusion Protein; ETV6::PDGFRB Fusion Protein;

NCIt definition : A fusion protein encoded by the ETV6/PDGFRB fusion gene. This protein is comprised of the N-terminal DNA binding helix-loop-helix domain of the transcription factor ETV6 protein fused to the C-terminal transmembrane and cytoplasmic domains of the beta-type platelet-derived growth factor receptor protein, including the protein kinase domain.;

NCIt note : The ETV6/PDGFRB fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99404;

UMLS CUI

C3274717;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ETV6/PDGFRB Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ETV6 Gene [NCIt concept]
- PDGFRB Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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