PCM1/RET Fusion Protein

Preferred Label : PCM1/RET Fusion Protein;

NCIt synonyms : PTC4/RET Fusion Protein; Pericentriolar Material 1/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein; PTC4-RET Fusion Protein; PCM1-RET Fusion Protein; PCM1::RET Fusion Protein;

NCIt definition : A fusion protein encoded by the PCM1/RET fusion gene. This protein is comprised of approximately 1600 N-terminal amino acids from the pericentriolar material 1 protein fused to almost the entire C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain.;

NCIt note : The PCM1/RET fusion protein is a constitutively active tyrosine kinase.;

Details

Origin ID

C99400;

UMLS CUI

C3274715;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- PCM1/RET Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- PCM1 Gene [NCIt concept]
- RET Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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