MLL/FNBP1 Fusion Gene

Preferred Label : MLL/FNBP1 Fusion Gene;

NCIt synonyms : FBP17/MLL Fusion Gene; MLL-FBP17 Fusion Gene; MLL/FBP17 Fusion Gene; MLL-FNBP1 Fusion Gene; KMT2A::FNBP1 Fusion Gene; MLL::FNBP1 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(9;11)(q34;q23) which fuses exon 7 of the MLL gene to most of the FNBP1 gene. This rearrangement is associated with acute myelogeneous leukemia.;

NCIt note : The presence of this fusion gene is associated with a poor prognosis. (Atlas of Genetics and Cytogenetics in Oncology and Haematology) This fusion also can arise from other complex chromosomal rearrangements including ins(11;9)(q23;q34) and inv(11)(q13;q23). (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

Details

Origin ID

C99327;

UMLS CUI

C1853553;

Automatic exact mappings (from CISMeF team)
- Formin-binding protein 1 [OMIM gene]
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/FNBP1 Fusion Protein [NCIt concept]
related_to_genetic_biomarker
- FNBP1 Gene [NCIt concept]
- KMT2A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients