BCR/PDGFRA Fusion Protein

Preferred Label : BCR/PDGFRA Fusion Protein;

NCIt synonyms : BCR-PDGFRA Fusion Protein; Breakpoint Cluster Region Protein/Alpha-Type Platelet-Derived Growth Factor Receptor Fusion Protein; BCR::PDGFRA Fusion Protein; Breakpoint Cluster Region Protein::Alpha-Type Platelet-Derived Growth Factor Receptor Fusion Protein;

NCIt definition : A fusion protein encoded by the BCR/PDGFRA fusion gene. This protein is comprised of the N-terminal oligomerization domain of the breakpoint cluster region protein fused to the C-terminal intracellular domain of the alpha-type platelet-derived growth factor receptor precursor protein, including the tyrosine kinase domains.;

NCIt note : The BCR/PDGFRA fusion protein is a constitutively dimerized and activated tyrosine kinase.;

Details

Origin ID

C99314;

UMLS CUI

C3274675;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BCR/PDGFRA Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- BCR Gene [NCIt concept]
- PDGFRA Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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