Preferred Label : Copper Cu 64-DOTA-Anti-HER3 Monoclonal Antibody U3-1287;
NCIt synonyms : 64Cu-DOTA-U3-1287; [64Cu]-DOTA-AMG 888;
NCIt definition : A radioimmunoconjugate of the fully human monoclonal antibody against the third member
of the epidermal growth factor receptor (EGFR), HER3 or ERBB3, conjugated with the
bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid
(DOTA) and labeled with radioisotope copper Cu 64, with potential diagnostic properties
upon positron emission tomography (PET) imaging and antineoplastic activity. The antibody
moiety of copper Cu 64-DOTA-anti-HER3 monoclonal antibody U3-1287 binds to and blocks
the activation of HER3, thereby resulting in the inhibition of EGFR-dependent PI3K/AKT
signaling and the subsequent inhibition of cellular proliferation and differentiation.
The Cu 64 moiety may be detected using positron emission tomography (PET), thereby
allowing the imaging and quantification of HER3-expressing tumor cells. HER3, which
lacks the kinase domain conveying ligand-binding signaling by forming heterodimers
with other EGFR members that have kinase activity, is frequently overexpressed in
solid tumors.;
NCI Metathesaurus CUI : CL433047;
Origin ID : C99217;
UMLS CUI : C3274613;
Semantic type(s)
- concept_is_in_subset
- has_target
