DEK/NUP214 Fusion Gene

Preferred Label : DEK/NUP214 Fusion Gene;

NCIt synonyms : NUP214/DEK Fusion Gene; DEK-CAN Fusion Gene; DEK-NUP214 Fusion Gene; DEK/CAN Fusion Gene; DEK::NUP214 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(6;9)(p23;q34) which fuses almost the entire DEK gene with the 5' side of exon 18 of the NUP214 gene. This rearrangement is associated with acute myeloid leukemia and myelodysplastic syndrome.;

Details

Origin ID

C99198;

UMLS CUI

C1861917;

Automatic exact mappings (from CISMeF team)
- Dek oncogene [OMIM gene]
- Nucleoporin, 214-kd [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DEK/NUP214 Fusion Protein [NCIt concept]
gene_has_abnormality
- t(6;9)(p22.3;q34.1) [NCIt concept]
gene_involved_in_molecular_abnormality
- DEK-NUP214 Fusion Protein Expression [NCIt concept]
- t(6;9)(p22.3;q34.1) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with t(6;9)(p22.3;q34.1); DEK-NUP214 [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(6;9)(p22.3;q34.1); DEK-NUP214 [NCIt concept]
genetic_biomarker_related_to
- t(6;9)(p22;q34)(DEK/NUP214) Fusion Transcript in Blood or Tissue by FISH [NCIt concept]
related_to_genetic_biomarker
- DEK Gene [NCIt concept]
- NUP214 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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