Acute Myeloid Leukemia with t(6;9)(p22.3;q34.1); DEK-NUP214

Preferred Label : Acute Myeloid Leukemia with t(6;9)(p22.3;q34.1); DEK-NUP214;

NCIt synonyms : Acute Myeloid Leukemia with t(6;9)(p22.3;q34); DEK-NUP214; Acute Myeloid Leukemia with t 6 9 p23 q34 DEK-NUP214; Acute Myeloid Leukemia with t(6;9)(p22.3;q34.1); DEK::NUP214; Acute Myeloid Leukemia with t(6;9) (p22.3;q34.1); DEK-NUP214 Fusion; Acute Myeloid Leukemia with t(6;9) (p22.3;q34.1); DEK::NUP214 Fusion;

NCIt related terms : AML with t(6;9)(p23;q34); DEK-NUP214; AML with t(6;9)(p23;q34.1);DEK-NUP214; Acute Myeloid Leukemia with t(6;9); AML with t(6;9)(p23;q34);DEK-NUP214; Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214;

NCIt definition : An acute myeloid leukemia associated with t(6;9)(p22.3;q34.1) resulting in DEK-NUP214(CAN) fusion protein expression. It is often associated with multilineage dysplasia and basophilia. It affects both children and adults and it usually has an unfavorable clinical outcome.;

Alternative definition : NICHD: An acute myeloid leukemia associated with t(6;9)(p22.3;q34), resulting in DEK-NUP214(CAN) fusion protein expression. It is often associated with multilineage dysplasia and basophilia. It is rare in children.;

Neoplastic status : Malignant;

ICD-O code : 9865/3;

Details

Origin ID

C82423;

UMLS CUI

C2826169;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukemia with DEK::NUP214 fusion (morphologic abnormality) [SNOMED CT concept]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Basophilia [NCIt concept]
- Bone Marrow Dysplasia Present [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia with DEK::NUP214 fusion (morphologic abnormality) [SNOMED CT concept]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- DEK/NUP214 Fusion Gene [NCIt concept]
- NUP214 Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- DEK/NUP214 Fusion Gene [NCIt concept]
- NUP214 Gene [NCIt concept]
- NUP214 wt Allele [NCIt concept]

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