NUP214/ABL1 310-333 kDa Fusion Protein

Preferred Label : NUP214/ABL1 310-333 kDa Fusion Protein;

NCIt synonyms : NUP214-ABL1 310-333 kDa Fusion Protein; Nuclear Pore Complex Protein Nup214/Tyrosine-Protein Kinase ABL1 310-333 kDa Fusion Protein; NUP214::ABL1 310-333 kDa Fusion Protein;

NCIt definition : A fusion protein encoded by the NUP214/ABL1 fusion gene variant 1. This protein is comprised of the N-terminal portion of the nuclear pore complex protein Nup214 including half of the nucleoporin GLFG repeat domain fused to the tyrosine-protein kinase ABL1 protein. There are multiple breakpoint sites in the nucleoporin GLFG repeat domain which lead to fusion proteins ranging from 310 to 333 kDa.;

NCIt note : The NUP214/ABL1 310-333 kDa fusion protein is a constitutively dimerized and activated tyrosine kinase.;

PubMed : 15361874;

Details

Origin ID

C99191;

UMLS CUI

C3274597;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- NUP214/ABL1 Fusion Gene Variant 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Tyrosine Phosphorylation [NCIt concept]
related_to_genetic_biomarker
- ABL1 Gene [NCIt concept]
- NUP214 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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