Preferred Label : Icotinib Hydrochloride;
NCIt synonyms : (1,4,7,10)Tetraoxacyclododecino(2,3-g)quinazolin-4-amine, N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-,
Hydrochloride (1:1); Icotinib HCl;
NCIt definition : The hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor
of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
Icotinib selectively inhibits the wild-type and several mutated forms of EGFR tyrosine
kinase. This may lead to an inhibition of EGFR-mediated signal transduction and may
inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, has been upregulated
in a variety of cancer cell types.;
UNII : JTD32I0J83;
InChIKey : PNNGXMJMUUJHAV-UHFFFAOYSA-N;
CAS number : 1204313-51-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1204313-51-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Conmana;
Molecule name : BPI-2009H;
NCI Metathesaurus CUI : CL524350;
Origin ID : C99160;
UMLS CUI : C3274573;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
