Preferred Label : p38 MAPK Inhibitor LY3007113;
NCIt definition : An orally active p38 mitogen-activated protein kinase (MAPK) inhibitor with potential
immunomodulating, anti-inflammatory, and antineoplastic activity. Upon administration,
LY3007113 inhibits the activity of p38, thereby preventing p38 MAPK-mediated signaling.
This may result in the inhibition of the production of proinflammatory cytokines and
the induction of tumor cell apoptosis. p38 MAPK, a serine/threonine protein kinase
often upregulated in cancer cells, plays a crucial part in the production of a variety
of cytokines involved in inflammation and cellular proliferation such as tumor necrosis
factor (TNF) and interleukin (IL)-1 and -6.;
Molecule name : LY3007113;
NCI Metathesaurus CUI : CL432952;
Origin ID : C99134;
UMLS CUI : C3274555;
Semantic type(s)
- concept_is_in_subset
- has_target
