NCIt definition : An orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2
p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin
binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional
activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53
interaction, p53 is not enzymatically degraded and the transcriptional activity of
p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis.
MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway,
is often overexpressed in cancer cells and has been implicated in cancer cell proliferation
and survival.;
Automatic exact mappings (from CISMeF team)