Preferred Label : Varlilumab;
NCIt synonyms : Immunoglobulin G1, Anti-(Human CD Antigen CD27) (Human Monoclonal CDX-1127 Clone 1f5
Heavy Chain), Disulfide with Human Monoclonal CDX-1127 Clone 1f5 Kappa-chain, Dimer;
NCIt definition : A human agonistic monoclonal antibody (MoAb) specific for CD27, with potential immunostimulating
and antineoplastic activity. Upon administration of varlilumab, this MoAb binds to
CD27 and may potentiate the immune response by increasing the cytotoxic T-lymphocyte
(CTL) response against CD27-expressing tumor cells. This may lead to growth inhibition
of CD27-expressing tumor cells. In addition, this agent may increase the proliferation
and activation of antigen-specific T lymphocytes upon co-administration of TAA-containing
vaccines, such as dendritic cell vaccines. CD27, a co-stimulatory molecule and member
of the tumor necrosis factor family overexpressed in certain tumor cell types, is
constitutively expressed on mature T-lymphocytes, memory B cells and natural killer
cells and plays an important role in NK cell mediated cytolytic activity and T and
B lymphocyte proliferation and activation.;
UNII : 0125DUV5XC;
CAS number : 1393344-72-3;
Molecule name : CDX-1127; CDX 1127;
NCI Metathesaurus CUI : CL432946;
Codes from synonyms : 530;
Origin ID : C99127;
UMLS CUI : C3896974;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
