" /> Encorafenib - CISMeF





Preferred Label : Encorafenib;

NCIt definition : An orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.;

UNII : 8L7891MRB6;

InChIKey : CMJCXYNUCSMDBY-ZDUSSCGKSA-N;

CAS number : 1269440-17-6;

Drug name : Braftovi;

Molecule name : LGX-818; LGX 818;

Codes from synonyms : 183;

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08/05/2025


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