Encorafenib - CISMeF

Preferred Label : Encorafenib;

NCIt definition : An orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.;

UNII : 8L7891MRB6;

InChIKey : CMJCXYNUCSMDBY-ZDUSSCGKSA-N;

CAS number : 1269440-17-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1269440-17-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Braftovi;

Molecule name : LGX-818; LGX 818;

Codes from synonyms : 183;

Details

Origin ID

C98283;

UMLS CUI

C4079208;

Automatic exact mappings (from CISMeF team)
- Encorafenib [ICD-11 Extension code]
- LGX818 [MeSH concept]
- encorafenib [ATC Code]
Currated CISMeF NLP mapping
- Encorafenib (substance) [SNOMED CT concept]
- encorafenib [MeSH Supplementary Concept]
- encorafenib [MeSH concept]
See also inter- (CISMeF)
- Product containing encorafenib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Encorafenib (substance) [SNOMED CT concept]
- Product containing encorafenib (medicinal product) [SNOMED CT concept]
- encorafenib [MeSH Supplementary Concept]
- encorafenib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
is_component_of_chemotherapy_regimen
- Binimetinib/Encorafenib Regimen [NCIt concept]
- Cetuximab/Encorafenib Regimen [NCIt concept]
- Encorafenib Regimen [NCIt concept]
- Encorafenib-Binimetinib-Cetuximab Regimen [NCIt concept]
- Encorafenib-Binimetinib-Panitumumab Regimen [NCIt concept]
- Encorafenib-Panitumumab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients