Thiazolidinedione Antidiabetic Agent

Preferred Label : Thiazolidinedione Antidiabetic Agent;

NCIt related terms : Thiazolidinedione;

NCIt definition : Any antidiabetic agent with the glitazone (thiazolidinedione) base structure with antihyperglycemic activity. Glitazone antidiabetic agents selectively bind to and stimulate the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This results in the selective transcription of a number of insulin-sensitive genes involved in glucose metabolism. This eventually enhances insulin sensitivity, reduces insulin resistance and decreases hepatic gluconeogenesis. PPARs function as transcription factors that regulate expressions of genes involved in cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), as well as tumorigenesis; PPARgamma is expressed at high levels in adipose tissue.;

Details

Origin ID

C98241;

UMLS CUI

C3273907;

Automatic exact mappings (from CISMeF team)
- 2,4-thiazolidinedione [MeSH Supplementary Concept]
- thiazolidinediones [MeSH concept]
- thiazolidinediones [ATC Code]
- thiazolidinediones [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Thiazolidinedione (substance) [SNOMED CT concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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