Dipeptidyl Peptidase-4 Inhibitor

Preferred Label : Dipeptidyl Peptidase-4 Inhibitor;

NCIt synonyms : DPP-4 Inhibitor;

NCIt definition : Any inhibitor of the proline-specific serine protease dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. DPP-4 inhibitors bind to DPP-4 and inhibit the breakdown of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This prolongs incretin activity, increases postprandial insulin release, decreases glucagon release, delays gastric emptying and lowers blood glucose levels. The risk for hypoglycemia is negligible with the use of DPP-4 inhibitors.;

Details

Origin ID

C98086;

UMLS CUI

C3537225;

Automatic exact mappings (from CISMeF team)
- Product containing dipeptidyl peptidase IV inhibitor (product) [SNOMED CT concept]
Currated CISMeF NLP mapping
- dipeptidyl-peptidase iv inhibitors [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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