Preferred Label : Lometrexol;
NCIt synonyms : L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-,
(R)-; L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-; Pyrido[2,3-d]pyrimidine, L-glutamic acid derivative (9CI); 6R-5,10-Dideazatetrahydrofolate; (6R)-DDATHF;
NCIt definition : A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer
of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase
(GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic
pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell
cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active
against tumors that are resistant to the folate antagonist methotrexate. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called antifolates.;
UNII : 6P3AVY8A7Q;
InChIKey : ZUQBAQVRAURMCL-DOMZBBRYSA-N;
CAS number : 106400-81-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 106400-81-1
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G-SRS /a ;
Chemical formula : C21H25N5O6;
NSC code : 660025;
Codes from synonyms : NSC0660025; CDR0000045386;
Origin ID : C979;
UMLS CUI : C0048852;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
