Preferred Label : Lometrexol Sodium;
NCIt definition : The sodium salt form of lometrexol, a folate analogue antimetabolite with antineoplastic
activity. As the stereoisomer of 5,10-dideazatetrahydrofolate, lometrexol selectively
inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes
the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA
synthesis and leading to an inhibition of tumor cell proliferation. The agent has
been shown to be active against tumors that are resistant to the folate antagonist
methotrexate, but causes severe, dose-limiting toxicities.;
UNII : US81N1145T;
InChIKey : SVJSWELRJWVPQD-KJWOGLQMSA-L;
CAS number : 120408-07-3;
Molecule name : LY264618 Disodium;
Chemical formula : C21H23N5O6.2Na;
Origin ID : C90623;
UMLS CUI : C2983806;
Semantic type(s)
- concept_is_in_subset
