Pegloticase - CISMeF

Preferred Label : Pegloticase;

NCIt synonyms : Oxidase, Urate (Synthetic Sus scrofa variant pigks-DN subunit), homotetramer, amide with alpha-carboxy-omega-methoxypoly(oxy-1,2-ethanediyl); Methoxypolyethylene Glycol Uricase; Polyethylene Glycol-uricase; Des-(1-6)-(7-threonine,46-threonine,291-lysine,301-serine)uricase (EC 1.7.3.3, urate oxidase) Sus scrofa (pig) tetramer, Non Acetylated, Carbamates with alpha-carboxy-omega-methoxypoly(oxyethylene);

NCIt definition : A recombinant modified mammalian urate oxidase (uricase) conjugated to monomethoxypolyethylene glycol (mPEG), that can be used to lower serum uric acid. Upon intravenous infusion, pegloticase catalyzes the oxidation of uric acid to allantoin, thereby lowering serum uric acid. Allantoin is an inert and water-soluble purine metabolite; it is readily eliminated, primarily by renal excretion.;

UNII : R581OT55EA;

CAS number : 885051-90-1;

Drug name : Puricase; Krystexxa;

Details

Origin ID

C97466;

UMLS CUI

C2350656;

Automatic exact mappings (from CISMeF team)
- Pegloticase [ICD-11 Extension code]
- Pegloticase (substance) [SNOMED CT concept]
- pegloticase [MeSH concept]
- pegloticase [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pegloticase (substance) [SNOMED CT concept]
- Product containing pegloticase (medicinal product) [SNOMED CT concept]
- pegloticase [MeSH concept]
- pegloticase [MeSH Supplementary Concept]
- pegloticase [ATC Code]
Validated automatic mappings to BTNT
- pegloticase [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients