Preferred Label : PI3K/mTOR Kinase Inhibitor DS-7423;
NCIt synonyms : Dual PI3 Kinase/mTOR Inhibitor DS-7423;
NCIt definition : An orally bioavailable inhibitor of phosphatidylinositol 3 kinase (PI3K) and mammalian
target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential
antineoplastic activity. PI3K/mTOR kinase inhibitor DS-7423 inhibits both PI3K kinase
and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in
susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth,
survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine
kinase downstream of PI3K, may also be activated independent of PI3K. Consequently,
this agent may potentially be more potent than an agent that inhibits either PI3K
kinase or mTOR kinase.;
Molecule name : DS-7423;
NCI Metathesaurus CUI : CL429785;
Origin ID : C97254;
UMLS CUI : C3273307;
Semantic type(s)
- concept_is_in_subset
- has_target
